Species reactivity: Human, baboon, monkey, cow, pig, sheep, goat, cat, dog, rabbit, mouse, rat, guinea pig, chicken.
Description: Actin is a major component of the cytoskeleton and is present in every cell type. Anti-Smooth Muscle Actin (SMA) does not stain cardiac or skeletal muscle, but it stains myofibroblasts and myoepithel. Used together with Muscle Specific Actin, leiomyosarcoma can be distinguished from rhabdomyosarcoma. In most cases of rhabdomyosarcoma, this antibody stains negative whereas Muscle Specific Actin is positive. Leiomyosarcomas are positive with both Muscle Specific Actin and SMA antibodies.
Description: Actin is a major component of the cytoskeleton. This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Anti-Muscle-Specific Actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative. This antibody is useful in the identification of rhabdoid cellular elements.