HISTOLS p504S/Cytokeratin 5

Catalog# 10144

 

Clone: 13H4 + XM26

Host: Validated combination of p504S specific rabbit monoclonal and CK5 specific mouse monoclonal antibodies

Species reactivity: Human. Others not tested.

Application: IHC-P

Description:

High expression of AMACR (p504S) protein is found in prostatic adenocarcinoma including pre-malignant lesions, like high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.

 

Cytokeratin 5 (CK5) protein is detectable in benign basal cells of the prostate epithelia. This antibody mixture is useful in diagnosis of prostate tumors.

HISTOLS p504S/p63 (PIN coctail)

Catalog# 10050

 

Clone: 13H4 + DBR16.1

Host: Validated mixture of p504S and p63 specific rabbit monoclonal antibodies

Species reactivity: Human. Others not tested.

Application: IHC-P

Description: p504S (AMACR, alpha-methylacyl-CoA-Racemase) is an enzyme involved in beta-oxidation of branched-chain fatty acids. It is expressed in prostatic adenocarcinomas but not in benign glands. Detection of p504S is helpful in distinguishing malignant from benign cells. P63 is detectable in benign basal cells of the prostate and in other epithelial tissues. Combined detection of p504S and p63 is useful for the diagnosis of prostate cancers. Anti-p504S is positive in cytoplasm of malignant and pre-malignant prostate glands, anti-p63 antibody is positive in benign glandular basal layer nuclei.

 

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