Species reactivity: Human, rat, mouse, rabbit, cat, dog, zebrafish.
Description: This monoclonal antibody reacts on normal and neoplastic cells of epithelial origin. It does not react on epidermal basal layer cells. Specificity: Cytokeratins 1, 2, 5, 6, 7, 8, 10, 11, 14, 16, 17, 18 and 19.
Description: : This antibody reacts with cytokeratin 5 intermediate filament protein. Basal cells of human epidermis express acidic CK 14 and basic CK 5. CK 5 is a 58 kDa protein, which is closely related to cytokeratin 6. Both are expressed in basal cell epithelioma, basal cells of prostate, urothelium, vagina and squamous cell carcinomas of the skin, tongue, epiglottis and the rectal-anal region. CK 5 can be useful in the distinction of mesotheliomas from most adenocarcinomas.
Description: Cytokeratin 7 antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile duct epithelial cells. Cytokeratin 7 distinguishes between lung and breast epithelium that stain positive, and colon and prostate epithelial cells that are negative. This antibody also reacts with many benign and malignant epithelial lesions, e.g. adenocarcinomas of the ovary, breast and lung. Transitional cell carcinomas are positive and prostate cancer is negative.
Description: This antibody is specific to human cytokeratin 18 of 45 kDa which belongs to a family of acidic type A and exists along with cytokeratin 8 in most simple ductal and glandular epithelia. This antibody does not react with squamous epithelium. It reacts with benign and malignant epithelial lesions, the majority of adenocarcinomas, and basal cell carcinomas.
Description: This antibody reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
Description: Cytokeratin 20 is less acidic than the other type I cytokeratins and is of particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 among various carcinomas.