Catalog # 10146
Tonsil, CD23 (E28-S)
Species reactivity: Human. Others not tested.
Description: CD23 is a 45 kDa protein. It is a member of the Ig family, and can be demonstrated in germinal centre B-cells, but it is not present in the resting cells of the surrounding mantle zone. Lymphomas arising from the mantle zone are generally negative for CD23, but most B-cell chronic lymphomocytic leukemias and low-grade B-cell lymphomas are positive, allowing to distinguish these conditions, which otherwise have a similar appearance. Reed–Sternberg cells are usually positive for CD23.