Catalog # 10099
Tonsil, CD21 (Q22-S)
Species reactivity: Human. Others not tested.
Description: CD21 (CR2, EBV-receptor) is present on mature B-cells and follicular dendritic cells (FDCs). This antibody can be used to demonstrate the FDC meshwork in lymphoid tissue. This feature can be useful in examining tissue where the normal germinal centers have been effaced by disease processes, such as HIV infection, some neoplastic conditions, like B-cell MALT lymphomas, mantle cell lymphoma, and some T cell lymphomas. Castleman's disease is typified by the presence of abnormal FDCs.