Host: Validated combination of TTF-1 and CK5 specific mouse monoclonal antibodies
Species reactivity: Human. Others not tested.
Description: Anti -TTF-1 (Thyroid Transcription Factor-1) is useful in differentiating primary adenocarcinomas of the lung from metastatic carcinomas of the breast, mediastinal germ cell tumors and malignant mesothelioma. TTF-1 positivity is typical of small cell lung cancer and adenocarcinoma of the lung. Loss of TTF-1 expression in non -small cell lung carcinoma has been associated with aggressive behavior of neoplasms. Cytokeratin 5 (CK5) positivity is typical of squamous cell cancer of lung. This antibody mixture is useful in the differential diagnosis of non-small cell lung cancer (NSCLC).